July 2, 2020

US$3 Million Grant Helps Research on Oxygen Deprivation During Pregnancy

Heather Jackson, Loma Linda University Health News

The National Heart, Lung, and Blood Institute of the United States awarded US$3.05 million to researchers from the Lawrence D. Long, MD Center for Perinatal Biology at Loma Linda University School of Medicine, allowing investigators to add a new element to their study portfolio of exploring the effects of oxygen deprivation — or hypoxia — on mother and baby during pregnancy.

Investigators will use the four-year grant toward the center’s research project, titled “Gestational Hypoxia and Programming of Maternal, Fetal, and Newborn Vascular Function.” Starting in July 2020, researchers will use the funds to search for mechanisms causing pregnancy complications of preeclampsia and developmental programming of cardiovascular disease from gestational hypoxia.

Hypoxia during gestation has profound adverse effects on the mother’s health and fetal development. Hypoxia is one of the most frequent and severe stresses on an organism's body regulation of metabolism, temperature, fluid composition, blood sugar, blood flow, and blood pressure. Worldwide, more than 140 million people live at risk of hypoxia in high-altitude environments. In addition, a large portion of pregnancy complications, including preeclampsia, smoking, and placental insufficiency, expose the fetus to chronic hypoxia.

The study’s principal investigator, Lubo Zhang, director of the Lawrence D. Longo, MD Center for Perinatal Biology, said he and his team look forward to making additional strides toward meaningful discoveries that could be lifesaving for mother and child.

“We are pleased and honored to receive this grant because the research it supports can change the lives of mothers and babies,” Zhang said. “The team’s overall vision is to build on the center’s prior accomplishments to formulate a highly innovative program for advancing and transforming the research field in understanding maternal, fetal, and newborn vascular function in response to hypoxia during gestation.”

In addition to this new research project, the investigator team headed by Zhang is currently conducting four studies on the effects of hypoxia. Those studies are funded by a Program Project grant from the United States National Institutes of Health (NIH). In 2016, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, an NIH entity, awarded the center a US$6.29 million grant to work on discoveries revealing oxygen deprivation’s effects on uterine blood flow, fetal cerebral circulation, and the impact of hypoxia on fat cell and metabolism.

Investigators found high-altitude hypoxia during gestation decreased uterine blood flow and increased the mother’s systemic arterial blood pressure. Researchers came to this conclusion after using an animal model of pregnant sheep acclimatized to high altitude above 10,000 feet (3,000 meters). In addition to maternal cardiovascular complications, the studies revealed that newborn lambs at high altitude showed significantly increased risk of persistent pulmonary hypertension — similar to humans. Investigators also found pregnancy complications and fetal hypoxia were associated with dysregulation of cerebral blood flow and increased risk of bleeding in the developing brain.

The original five-year NIH grant will expire in March of 2021. With a new National Heart, Lung, and Blood Institute grant available, the research team is looking forward to exploring the topic for another four years.

The new grant was secured with help from Rep. Pete Aguilar, U.S. representative for California’s 31st congressional district.

“Loma Linda University Health is a point of pride for our region, and the lifesaving research of Dr. Zhang and his team is exciting and inspiring,” Aguilar said. “As vice-chair of the House Appropriations Committee and LLUH’s representative in Congress, I’m proud to support their work and will continue to advocate for the funding that makes these groundbreaking studies possible.”

The original version of this story was posted on the Loma Linda University Health news site.